MIC 419

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Learning Objectives: Tumor Immunology

Reading Assignment:

Janeway et al. Chapter 14 pp 630-642 or Parham Chapter 12 pp 412-429

Supplementary Materials: Tumor Immunology, ToolBox

Tumor Immunology summarizes the interactions between the immune system and tumors. It discusses causes of tumors and the nature of tumor antigens, reviews the immune mechanisms available to reject tumor cells, and describes how tumors avoid immune elimination.

When you finish Tumor Immunology, you should be able to

• Define and correctly use the terms neoplasm, benign and malignant tumors, metastasis, and malignant transformation.
• Explain the relationship of proto-oncogenes, oncogenes, and tumor suppressor genes to malignant transformation.
• Compare innate (DC and macrophage) and adaptive (B and T cell) immune recognition of tumor-specific antigens (TSAs) and tumor-associated antigens (TAAs) with recognition of bacterial antigens.
• Describe and explain the cellular and humoral mechanisms by which the immune system could eliminate tumors.
• Describe and explain the mechanisms tumors use to avoid immune elimination.
• Describe and explain immunotherapies for tumors.
• Propose a vaccine against a specific tumor.
• Apply this information to a clinical case.

http://microvet.arizona.edu/Courses/MIC419/LearningObjectives/LOTumorImmunol.htm
Written by Janet M. Decker, PhD       jdecker@u.arizona.edu
Last modified April 16, 2007