Learning Objectives: TCR&MHC

Immunology 519/419H

Learning Objectives: Antigen Processing and Presentation

Reading Assignment: Janeway et al. Immunobiology Ch 5

Supplementary Materials: MHC, TCR, ToolBox

TCR only binds antigen peptides that are presented on Class I or Class II MHC. T cells are specialized to recognize cytosolic pathogens (presented on Class I MHC to CD8 T cells) or extracellular/vesicular pathogens (presented on Class II MHC to CD4 T cells). This unit describes the organization and inheritance of MHC genes and antigen processing and presentation

The Learning Objectives pages list the key concepts you should know from each section of the course. You are also expected to know the words bolded in the text. In addition to Immunobiology by Janeway et al., study aids include online Tutorials with study questions and a ToolBox containing a Glossary, Reading and Writing About Immunology, and information about immunological techniques.

When you finish Antigen Processing and Presentation, you should be able to

REVIEW: Sketch MHC Class I and Class II molecules. Compare them with each other and with BCR and TCR molecules. What is the Ig superfamily of molecules?
Describe antigen processing and presentation on MHC Class I. Which cells are capable of presenting antigen on MHC Class I? Which T cells see/recognize/bind peptide on MHC Class I?
Describe antigen processing and presentation on MHC Class II. Which cells are capable of presenting antigen on MHC Class II? Which T cells see/recognize/bind peptide on MHC Class II?
Define a superantigen. Give a specific example and explain what makes it "super".
Explain inheritance of MHC Class I and Class II molecules and describe how this impacts organ transplantation.
Explain how a single Class I MHC can present many different peptides.
Describe flow cytometry and be able to interpret data obtained by flow
Apply this information to a clinical case - be able to compare and contrast T and B cell recognition molecules.

http://microvet.arizona.edu/Courses/MIC419/LOTCR&MHC.html
Written by Janet M. Decker, PhD jdecker@u.arizona.edu
Last modified September 16, 2004