Reading Assignment: Janeway et al. Chapter 3 Antigen Recognition by B-cell and T-cell Receptors
Supplementary Materials: Decker Tutorials Antigen, Antibody, Antibody Genes, TCR, ToolBox
Antibody (Ig, BCR) and T cell receptor (TCR) are the specific proteins that B cell and T cells use to recognize antigen, receiving signals that begin their activation process to effector B cell (plasma cells) and effector T cells (cytotoxic or regulatory T cells). B cells bind antigen directly, while T cells must bind antigen peptide complexed with Major Histocompatibility Complex (MHC) proteins on the membranes of infected or antigen-presenting cells. This unit describes the structure and function of antibody, TCR, and MHC, as well as the T cell co-receptor molecules CD4 and CD8, and discusses how these receptor molecules bind antigen.
The Learning Objectives pages list the key concepts you should know from each section of the course. You are also expected to know the words bolded in the text. In addition to Immunobiology by Janeway et al., study aids include online Tutorials with study questions and a ToolBox containing a Glossary, Reading and Writing About Immunology, and information about immunological techniques.
When you finish Antigen Receptors, you should be able to
Return to Immunology 519/419H Home page
http://microvet.arizona.edu/Courses/MIC419/LOAgReceptors.html
Written by Janet M. Decker, PhD jdecker@u.arizona.edu
Last modified
August 31, 2006