Michael W. Riggs
Associate
Professor, Department of Veterinary
Science and Microbiology, College of Agriculture and Life Sciences
Joint Associate Professor,
Department of Pathology, College of Medicine
Veterinary
Science and Microbiology
Building
e-mail:mriggs@u.arizona.edu
University
of
Arizona
Fax: (520) 621-6366
Tucson,
AZ
85721
Phone: (520) 621-8445
Education
·
B.S.,
Texas A & M University
· D.V.M., Texas A & M
University,
1983
· Ph.D., Immunoparasitology and
Comparative Pathology, Washington State University,
Department of Veterinary Microbiology and Pathology, 1988
· Residency, Veterinary Anatomic
Pathology, Washington Animal Disease Diagnostic
Laboratory, 1983-1987
· Diplomate, American College of
Veterinary Pathologists, 1988
Major Fields
·
Immunoparasitology
· Veterinary
Diagnostic Pathology
· Experimental
Pathology – Veterinary and Comparative
Selected
Honors and Awards
·
Thomas S. Gathright Award for Academic Excellence, Texas A
& M University (1979)
· Diamond
Laboratories Service Award, Texas A & M University (1981)
· Pfizer
Leadership Award, Texas A & M University (1982)
· Charles
E. Cornelius Young Investigator Faculty Research Award, Univ. of
Florida (1989)
· Teacher
of the Year for the Veterinary Class of 1992, University of Florida
(1990)
· Outstanding
Faculty Achievement and Performance Award, University of Florida (1990)
· Teaching
Excellence Award in the Basic Sciences, Florida Student Chapter of the
American
Veterinary
Medical Association, University of Florida (1991)
· Teacher
of the Year for the Veterinary Class of 1993, University of Florida
(1991)
· Teacher
of the Year for the College of Veterinary Medicine, University of
Florida (1991)
· Outstanding
Faculty Advisor Award, Pre-Veterinary Student Organization, University
of
Arizona
(1997, 2001)
· Outstanding
Teaching Award for the Department of Veterinary Science and
Microbiology,
University of Arizona (2001)
·
Faculty Award for Outstanding Teaching in the College of Agriculture
and Life Sciences,
University of Arizona (2002)
Research
Dr.
Riggs
joined the University of Arizona in 1992 after serving as an assistant
professor in the Department of Comparative and Experimental Pathology
at the University of Florida (1988-1991). His research interests center
on the immunobiology and molecular pathogenesis of parasitic protozoal
diseases of zoonotic importance. Current research is focused on
development of recombinant and synthetic
vaccines for cryptosporidiosis; immunotherapy of cryptosporidiosis;
definition
of the molecular pathogenesis of host cell recognition, attachment, and
invasion by Cryptosporidium parvum; structural characterization
of C. parvum glycoprotein ligands; animal model development;
and improved methods for
diagnosis and detection.
Since 1989, his research program has been supported by funding as
Principal
Investigator from the NIH, USDA NRICGP, private foundations, and
industry.
He has contributed as senior inventor or co-inventor on five patents
resulting
from research discoveries. National research-related service activities
have
included memberships on the USDA NRI Competitive Grants Program and NIH
AIDS-Related
Opportunistic Infections Study Sections, and a federal appointment as
Chair
of the Immunology/Parasitology/Production Disease/Toxicology Study
Section
for the USDA NRI Competitive Grants Program.
Teaching
While a
faculty member at the University of Florida, Dr. Riggs' primary
assignments were in teaching and diagnostic pathology. He directed the Systemic
Pathology course and participated in teaching Applied Pathology
in the Professional Veterinary Curriculum, and was involved
in training Residents in Veterinary Anatomic Pathology through the
College's Necropsy and Surgical Pathology Services. Since joining the
University of Arizona, Dr. Riggs has taught
a 4-5 credit course in Comparative General Pathology to senior pre-professional undergraduate
students
(Mechanisms of
Disease VSC 423, 4 cr) and graduate
students (VSC 523, 5 cr), and
continues to mentor graduate students.
Academic service
activities have
included Faculty Advisor to the Pre-Veterinary Student Organization
(1994-pres),
membership on the departmental Instructional Programs Committee
(1992-2000),
Pathobiology Graduate Program Committee (2001-2004), College of
Agriculture
and Life Sciences Curriculum Committee (1994-1998), University Hearing
Board
(2001-pres), and Institutional Biosafety Committee (2001-pres).
Selected
Research Publications (last 5 years)
Priest, J.W., A. Mehlert, M.J.
Arrowood,
M.W. Riggs, and M.A.J. Ferguson. 2003.
Characterization of a low molecular weight glycolipid antigen from Cryptosporidium
parvum.
Journal of
Biological
Chemistry 278:52212-52222.
Riggs, M.W. 2002. Recent Advances in Cryptosporidiosis: The
Immune Response. Microbes and Infection 4:1067-1080.
Riggs, M.W.,
D.A. Schaefer, S.J. Kapil, L. Barley-Maloney, and L.E. Perryman. 2002.
Efficacy of Monoclonal Antibodies Against Defined Antigens for Passive
Immunotherapy of Chronic Gastrointestinal Cryptosporidiosis. Antimicrobial
Agents and Chemotherapy 46:275-282.
Wyatt, C.R.,
W.J. Barrett, E.J. Brackett, D.A. Schaefer, and M.W. Riggs. 2002.
Association of IL-10 Expression by Mucosal Lymphocytes with Increased
Expression of Cryptosporidium parvum Epitopes in Infected
Epithelium. Journal of Parasitology 88:281-286.
Riggs, M.W.,
D.A. Schaefer, S.J. Kapil, L. Barley-Maloney, L.E. Perryman, and M.R.
McNeil. 2001. Targeted Disruption of CSL Ligand – Host Cell Receptor
Interaction in Treatment of Cryptosporidium parvum Infection. Journal
of Eukaryotic Microbiology 48:44S-46S.
* Langer, R.C. D.A. Schaefer, and M.W. Riggs. 2001. Characterization of
an Intestinal Epithelial Cell
Receptor Recognized by the Cryptosporidium parvum Sporozoite
Ligand CSL. Infection and
Immunity 69:1661-1670.
* Schaefer, D.A., B.A. Auerbach-Dixon, and M.W. Riggs. 2000.
Characterization and Formulation of
Multiple Epitope-Specific Neutralizing Monoclonal Antibodies for
Passive Immunization Against
Cryptosporidiosis. Infection
and Immunity 68:2608-2616.
* Langer, R.C. and M.W. Riggs. 1999. Cryptosporidium parvum
Apical Complex Glycoprotein CSL
Contains a Sporozoite Ligand for Intestinal Epithelial Cells. Infection
and Immunity 67:5282-5291.
Adjei,
A.A., J.T. Jones, M.W. Riggs, and F.J. Enriquez. 1999. Evidence of
Thymus- independent Local and Systemic Antibody Responses to Cryptosporidium
parvum Infection in Nude Mice. 1999. Infection and Immunity
67:3947-3951.
Riggs, M.W.,
M.R. McNeil, L.E. Perryman, A. Stone, M. Scherman, and R. O'Connor.
1999. Cryptosporidium parvum Sporozoite Pellicle Antigen
Recognized by a Neutralizing Monoclonal Antibody is a Beta-mannosylated
Glycolipid. Infection and Immunity 67:1317-22.
Enriquez, F.J.
and M.W. Riggs. 1998. Role of Immunoglobulin A Monoclonal Antibodies
Against P23 in Controlling Murine Cryptosporidium parvum
Infection. Infection and Immunity 66:4469-4473.
Riggs, M.W.
1997. Immunology: Host Response and Development of Passive
Immunotherapy and Vaccines. In: "Cryptosporidium and
Cryptosporidiosis". R. Fayer, Ed., CRC Press, Boca Raton, Florida, pp.
129-162.
Riggs, M.W.,
A.L. Stone, P.A. Yount, R.C. Larger, M.J. Arrowood, and D.L. Bentley.
1997. Protective Monoclonal Antibody Defines a Circumsporozoite Like
Glycoprotein Exoantigen of Cryptosporidium parvum Sporozoites
and Merozoites. Journal of Immunology 158:1787-1795.
* graduate
student
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